Host defense mechanisms against Salmonella infection
نویسندگان
چکیده
منابع مشابه
Circulating Lipoproteins Are a Crucial Component of Host Defense against Invasive Salmonella typhimurium Infection
BACKGROUND Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines. METHODS/PRINCIPAL FINDINGS Low density lipoprotein receptor deficient (LDLR-/-) mice, with a 7-fold increase in LDL, are resistant against infection with Salmonella typhimurium (survival 100% vs 5%,...
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The outcome of an infection depends on the balance between host resistance and bacterial virulence. Here, we show that the late endosomal adaptor p14 (also known as LAMTOR2) is one of the components for cellular host defense against the intracellular pathogen Salmonella enterica serovar Typhimurium. During Salmonella infection, the complex of p14 and MP1 is required for the accurately timed tra...
متن کاملPulmonary host defense mechanisms.
T he major function of the respiratory system is to procure oxygen from the external environment and to eliminate carbon dioxide from the body at rates required by tissue metabolism. Unfortunately, ambient inspired air contains not only oxygen which is vital to survival, but also noxious gases and a multitude of particulates, including viable microorganisms, which the lungs must exclude to main...
متن کاملThymus-dependent control of host defense mechanisms against Trypanosoma cruzi infection.
Congenitally athymic homozygous (nu/nu) mice were shown to be significantly more susceptible to Trypanosoma cruzi infection than their thymus-bearing heterozygous (nu/+) littermates, as measured by increased parasitemia, mortality rate, and shortened survival time. In addition, transplantation of neonatal thymus into athymic mice reestablished normal levels of resistance to T. cruzi, i.e., comp...
متن کاملEpithelial antimicrobial peptides in host defense against infection
One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, alpha-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. beta-Defensins and LL-...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2004
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.27.367